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Some clinicians prefer to avoid the DAC version specifically because pulsatile release is more physiological
The nausea, vomiting, and diarrhea commonly associated with semaglutide therapy can lead to reduced fluid intake or increased fluid loss, potentially resulting in dry mouth (xerostomia)
Before each use: Gently invert the bottle to redistribute the solution
Reassess therapy if frailty or falls risk emerges
In REDEFINE 2, which included participants with type 2 diabetes (a population that typically shows lower weight loss with any intervention), CagriSema achieved 13.7% weight loss compared to 3.4% with placebo
But what was striking is the challenge, and this is one of the first important questions about, when you had the extended half-life of the first GLP-1 drug, that instead of having to take multiple times a day, you could actually, with liraglutide get to a point where you were starting to get to an extended half-life
